2006-11 — Joseph E. LeDoux

2011

Debiec J, Bush DE, LeDoux JE. Noradrenergic enhancement of reconsolidation in the amygdala impairs extinction of conditioned fear in rats--a possible mechanism for the persistence of traumatic memories in PTSD. Depress Anxiety. 2011 Mar;28(3):186-93. doi: 10.1002/da.20803. <Abstract><Full>

Díaz-Mataix L, Debiec J, LeDoux JE, Doyère V.Sensory-specific associations stored in the lateral amygdala allow for selective alteration of fear memories. J Neurosci. 2011 Jun 29;31(26):9538-43. <Abstract><Full>

Hoeffer CA, Cowansage KK, Arnold EC, Banko JL, Moerke NJ, Rodriguez R, Schmidt EK, Klosi E, Chorev M, Lloyd RE, Pierre P, Wagner G, LeDoux JE, Klann E. Inhibition of the interactions between eukaryotic initiation factors 4E and 4G impairs long-term associative memory consolidation but not reconsolidation.Proc Natl Acad Sci U S A. 2011 Feb 22;108(8):3383-8. Epub 2011 Feb 2. <Abstract><Full>

Johansen JP, Wolff SB, Lüthi A, Ledoux JE. Controlling the Elements: An Optogenetic Approach to Understanding the Neural Circuits of Fear. Biol Psychiatry. 2011 Dec 12. <Abstract><Full>

Joshua P. Johansen, Christopher K. Cain, Linnaea E. Ostroff, Joseph E. LeDoux Molecular Mechanisms of Fear Learning and Memory. 28 October 2011 Cell 147(3) pp. 509 - 524 <Abstract><Full>

Johnson LR1, Hou M2, Prager E M1, LeDoux J2 Regulation of the fear network by mediators of stress: Norepinephrine alters the balance between Cortical and Subcortical afferent excitation of the Lateral Amygdala Front Behav Neurosci. 2011;5:23. Epub 2011 May 23. <Abstract>

LeDoux JE Music and the brain, literally Front Hum Neurosci. 2011;5:54. Epub 2011 May 27. <Full>

Ostroff LE. Recalling the future. Nat 474(7349) (2011) <Full>

2010

David E A . Bush, Ellen M . Caparosa, Anna Gekker and Joseph LeDoux Beta-adrenergic receptors in the lateral nucleus of the amygdala contribute to the acquisition but not the consolidation of auditory fear conditioning. Front Behav Neurosci. (Paper pending published: 04 July 2010); <Abstract><Full>

Choi JS, Cain CK, Ledoux JE. The role of amygdala nuclei in the expression of auditory signaled two-way active avoidance in rats. Learn Mem. 2010 Feb 26;17(3):139-47. <Abstract><full>

Cowansage KK, Ledoux JE, Monfils MH.Brain-Derived Neurotrophic Factor: A Dynamic Gatekeeper of Neural Plasticity.Curr Mol Pharmacol. 2010 Jan;3(1):12-29.<Abstract>

Cunha C1, 2, Monfils MH 1, 3 and LeDoux JE.GABAC receptors in the lateral amygdala: a possible novel target for the treatment of fear and anxiety disorders? Front Behav Neurosci. 2010 Mar 12;4:6.<Abstract><Full>

Daniela Schiller, Marie-H. Monfils, Candace M. Raio, David C. Johnson, Joseph E. LeDoux & Elizabeth A. Phelps. Preventing the return of fear in humans using reconsolidation update mechanisms. Nature 463, 49-53 (7 January 2010) <Full>
See also:
*Nature News & Views by Gregory Quirk and Mohammed Milad
*Nature video feature

Debiec J, Díaz-Mataix L, Bush DE, Doyère V, Ledoux JE.The amygdala encodes specific sensory features of an aversive reinforcer.Nat Neurosci. 2010 Mar 28. <Abstract><Full>

Farb C.R. Chang W, and LeDoux J.E. Ultrastructural characterization of noradrenergic axons and beta-adrenergic receptors in the lateral nucleus of the amygdala <Abstract><Full>

Johansen JP, Tarpley JW, Ledoux JE, Blair HT. Neural substrates for expectation-modulated fear learning in the amygdala and periaqueductal gray. Nat Neurosci. 2010 Jul 4.<Abstract><Full>

Johansen JP, Hamanaka H, Monfils MH, Behnia R, Deisseroth K, Blair HT, LeDoux JE.Optical activation of lateral amygdala pyramidal cells instructs associative fear learning. Proc Natl Acad Sci U S A. 2010 Jul 13;107(28):12692-7. Epub 2010 Jun 25.<Abstract><Full>

Lázaro-Muñoz G, Ledoux JE, Cain CK. Sidman Instrumental Avoidance Initially Depends on Lateral and Basal Amygdala and Is Constrained by Central Amygdala-Mediated Pavlovian Processes. Biol Psychiatry. 2010 Jan 26.<Abstract><Full>

Lazzaro SC, Hou M, Cunha C, LeDoux JE, Cain CK. Antagonism of lateral amygdala alpha1-adrenergic receptors facilitates fear conditioning and long-term potentiation. Learn Mem. 2010 Sep 24;17(10):489-93. Print 2010.<Abstract><Full>

Nedelescu H, Kelso CM, Lázaro-Muñoz G, Purpura M, Cain CK, Ledoux JE, Aoki C.Endogenous GluR1-containing AMPA receptors translocate to asymmetric synapses in the lateral amygdala during the early phase of fear memory formation: an electron microscopic immunocytochemical study. J Comp Neurol. 2010 Dec 1;518(23):4723-39. <Abstract><Full>

Ostroff LE, Cain CK, Bedont J, Monfils MH, Ledoux JE.Fear and safety learning differentially affect synapse size and dendritic translation in the lateral amygdala. Proc Natl Acad Sci U S A. 2010 May 3. <Abstract><Full>

Schiller D, Monfils MH, Raio CM, Johnson DC, Ledoux JE, Phelps EA.Preventing the return of fear in humans using reconsolidation update mechanisms.Nature. 2010 Jan 7;463(7277):49-53. Epub 2009 Dec 9.<Abstract><Full>

Sigurðsson T, Cain CK, Doyère V, Ledoux JE Asymmetries in long-term and short-term plasticity at thalamic and cortical inputs to the amygdala in vivo.Eur J Neurosci. 2010 Jan 13.<Abstract><Full>

2009

Delgado MR, Jou RL, Ledoux JE, Phelps EA. Avoiding negative outcomes: tracking the mechanisms of avoidance learning in humans during fear conditioning. Front Behav Neurosci. 2009;3:33. Epub 2009 Oct 1.<Abstract><Full>

Mauricio R. Delgado, Rita L. Jou, Joseph E. LeDoux, and Elizabeth A. Phelps Avoiding Negative Outcomes: Tracking the Mechanisms of Avoidance Learning in Humans During Fear Conditioning.Front Behav Neurosci. 2009; 3: 33. <full>

Lamprecht R, Dracheva S, Assoun S, Ledoux JE.Fear conditioning induces distinct patterns of gene expression in lateral amygdala.Genes Brain Behav. 2009 Jun 23. <Abstract><Full>

Enrique Lanuza, Jose Moncho-Bogani, and Joseph E. LeDoux Unconditioned Stimulus Pathways to the Amygdala: Effects of Lesions of the Posterior Intralaminar Thalamus on Footshock-Induced c-Fos Expression in the Subdivisions of the Lateral Amygdala.Neuroscience. 2008 August 26; 155(3): 959–968. <full>

Monfils MH, Cowansage KK, Klann E, LeDoux JE. .Extinction-reconsolidation boundaries: key to persistent attenuation of fear memories.Science. 2009 May 15;324(5929):951-5. Epub 2009 Apr 2.<Full>

Jason J. Radley, Claudia Farb, Yong He, William G.M. Janssen, Sarina M. Rodrigues, Luke R. Johnson, Patrick R. Hof, Joseph E. LeDoux, and John H. Morrison The distribution of NMDA and AMPA receptor subunits at thalamo-amygdala dendritic spines. Brain Res. 2007 February 23; 1134(1): 87–94.<Full>

Johnson LR, Ledoux JE, Doyère V. Hebbian reverberations in emotional memory micro circuits. Front Neurosci. 2009 Sep;3(2):198-205. Epub .<Abstract><Full>

Rodrigues SM, Ledoux JE, Sapolsky RM.The influence of stress hormones on fear circuitry.Annu Rev Neurosci. 2009;32:289-313.<Full>

Schiller D and Johansen J . Prelimbic Prefrontal Neurons Drive Fear Expression: A Clue for Extinction–Reconsolidation Interactions
J. Neurosci. 2009;29 13432-13434 <Full>

Francisco Sotres-Bayon, Llorenç Diaz-Mataix, David E.A. Bush, and Joseph E. LeDoux Dissociable roles for the ventromedial prefrontal cortex and amygdala in fear extinction: NR2B contribution.Cereb Cortex. 2009 February; 19(2): 474–482. <Full>

2008

Delgado MR, Nearing KI, Ledoux JE, Phelps EA. Neural circuitry underlying the regulation of conditioned fear and its relation to extinction.Neuron. 2008 Sep 11;59(5):829-38. <Abstract> <Full>

Duvarci S, Nader K, LeDoux JE.De novo mRNA synthesis is required for both consolidation and reconsolidation of fear memories in the amygdala.Learn Mem. 2008 Oct 2;15(10):747-55. Print 2008.<Abstract> <Full>

Joseph E. LeDoux: Amygdala. Scholarpedia (2008)- in process.

Lanuza E, Moncho-Bogani J, Ledoux JE. Unconditioned stimulus pathways to the amygdala: Effects of lesions of the posterior intralaminar thalamus on foot-shock-induced c-Fos expression in the subdivisions of the lateral amygdala. Neuroscience. 2008 Aug 26;155(3):959-68. Epub 2008 Jun 19.<Abstract><Full>

Johnson LR, Hou M, Ponce-Alvarez A, Gribelyuk L, Alphs H, Albert Jr L, Brown BL, LeDoux J and Doyere V (2008). A recurrent network in the lateral amygdala: a mechanism for coincidence detection. Front Neural Circuits. 2008; 2: 3. <Abstract><Full>

Schiller D, Cain CK, Curley NG, Schwartz JS, Stern SA, Ledoux JE, Phelps EA. Evidence for recovery of fear following immediate extinction in rats and humans.1: Learn Mem. 2008 May 28;15(6):394-402. <Abstract><Full>

Schiller D, Levy I, Niv Y, LeDoux JE, Phelps EA. (2008) From fear to
safety and back - reversal of fear in the human brain. The Journal of
Neuroscience 28(45):11517-11525. <Abstract> <Full>

Sotres-Bayon F, Diaz-Mataix L, Bush DE, Ledoux JE. Dissociable Roles for the Ventromedial Prefrontal Cortex and Amygdala in Fear Extinction: NR2B Contribution.Cereb Cortex. 2008 Jun 17. <Abstract><Full>

tion: NR2B contribution.Cereb Cortex. 2009 February; 19(2): 474–482. <Full>

2007

Burghardt NS, Bush DE, McEwen BS, Ledoux JE.Acute Selective Serotonin Reuptake Inhibitors Increase Conditioned Fear Expression: Blockade With a 5-HT(2C) Receptor Antagonist. Biol Psychiatry. 2007 May 22; [Epub ahead of print] <Abstract><Full>

Bush DE, Sotres-Bayon F, Ledoux JE.Individual differences in fear: Isolating fear reactivity and fear recovery phenotypes. J Trauma Stress. 2007 Aug 22;20(4):413-422 [Epub ahead of print] <Abstract><Full>

Butler T, Pan H, Tuescher O, Engelien A, Goldstein M, Epstein J, Weisholtz D, Root JC, Protopopescu X, Cunningham-Bussel AC, Chang L, Xie XH, Chen Q, Phelps EA, Ledoux JE, Stern E, Silbersweig DA. Human fear-related motor neurocircuitry.Neuroscience. 2007 Nov 30;150(1):1-7. Epub 2007 <Abstract><Full>

Cain CK, Ledoux JE. Escape from fear: A detailed behavioral analysis of two atypical responses reinforced by CS termination.J Exp Psychol Anim Behav Process. 2007 Oct;33(4):451-63. PMID: 17924792 [PubMed - in process] <Abstract> <Full>

Doyère V, Debiec J, Monfils MH, Schafe GE, LeDoux JE.. Synapse-specific reconsolidation of distinct fear memories in the lateral amygdala. Nature Neuroscience - 10, 414 - 416 (2007). <Abstract> <Full>

Hu H, Real E, Takamiya K, Kang MG, Ledoux J, Huganir RL, Malinow R.
Emotion enhances learning via norepinephrine regulation of AMPA-receptor trafficking.Cell. 2007 Oct 5;131(1):160-73. <Abstract><Full>

Kopec CD, Kessels HW, Bush DE, Cain CK, Ledoux JE, Malinow R. A robust automated method to analyze rodent motion during fear conditioning.
Neuropharmacology. 2007 Jan;52(1):228-33. Epub 2006 Aug 22. <Abstract><Full>

Joseph E. LeDoux: Emotional Memory. Scholarpedia (2007), 2(7):180

LeDoux J.The amygdala.Curr Biol. 2007 Oct 23;17(20):R868-74. Review. No abstract available. <full>

Monfils MH, Cowansage KK, LeDoux JE.Brain-derived neurotrophic factor: linking fear learning to memory consolidation.Mol Pharmacol. 2007 Aug;72(2):235-7. Epub 2007 May 23. <Abstract><Full>

Protopopescu X, Pan H, Tuescher O, Cloitre M, Goldstein M, Engelien A, Yang Y, Gorman J, LeDoux J, Stern E, Silbersweig D.Increased brainstem volume in panic disorder: a voxel-based morphometric study.Neuroreport. 2006 Mar 20;17(4):361-3. <Abstract>

Radley JJ, Farb CR, He Y, Janssen WG, Rodrigues SM, Johnson LR, Hof PR, Ledoux JE, Morrison JH.Distribution of NMDA and AMPA receptor subunits at thalamo-amygdaloid dendritic spines.Brain Res. 2007 Jan 4; [Epub ahead of print] <Abstract><Full>

Sigurdsson T, Doyere V, Cain CK, Ledoux JE.Long-term potentiation in the amygdala: A cellular mechanism of fear learning and memory.
Neuropharmacology. 2007 Jan;52(1):215-27. Epub 2006 Aug 21. <Abstract><Full>

Sotres-Bayon F, Bush DE, Ledoux JE.Acquisition of Fear Extinction Requires Activation of NR2B-Containing NMDA Receptors in the Lateral Amygdala.
Neuropsychopharmacology. 2007 Jan 10; <Abstract><Full>

Yehuda R, LeDoux J. Response Variation following Trauma: A Translational Neuroscience Approach to Understanding PTSD. Neuron. 2007 Oct 4;56(1):19-32. Review. <Abstract> <Full

2006

Debiec J, Doyere V, Nader K, Ledoux JE.
Directly reactivated, but not indirectly reactivated, memories undergo reconsolidation in the amygdala.Proc Natl Acad Sci U S A. 2006 Feb 28;103(9):3428-33. Epub 2006 Feb 21. <Abstract><Full article>

Debiec J, Ledoux JE. Noradrenergic signaling in the amygdala contributes to the reconsolidation of fear memory: treatment implications for PTSD.
Ann N Y Acad Sci. 2006 Jul;1071:521-4. <Abstract>

Kopec CD, Kessels HW, Bush DE, Cain CK, Ledoux JE, Malinow R. A robust automated method to analyze rodent motion during fear conditioning.
Neuropharmacology. 2006 Aug 18;<Abstract><Full article>

Lamprecht R, Margulies DS, Farb CR, Hou M, Johnson LR, Ledoux JE.
Myosin light chain kinase regulates synaptic plasticity and fear learning in the lateral amygdala. Neuroscience. 2006 Feb 28. <Abstract><Full article>

Lamprecht R, Farb CR, Rodrigues SM, LeDoux JE.Fear conditioning drives profilin into amygdala dendritic spines.Nat Neurosci. 2006 Apr;9(4):481-3. Epub 2006 Mar 19. <Abstract><Full article>

Radley JJ, Johnson LR, Janssen WG, Martino J, Lamprecht R, Hof PR, LeDoux JE, Morrison JH.Associative Pavlovian conditioning leads to an increase in spinophilin-immunoreactive dendritic spines in the lateral amygdala.
Eur J Neurosci. 2006 Aug;24(3):876-84. <Abstract><Full article>

Sotres-Bayon F, Cain CK, Ledoux JE. Brain Mechanisms of Fear Extinction: Historical Perspectives on the Contribution of Prefrontal Cortex. <Abstract><Full article>

Wilensky AE, Schafe GE, Kristensen MP, LeDoux JE.Rethinking the fear circuit: the central nucleus of the amygdala is required for the acquisition, consolidation, and expression of Pavlovian fear conditioning<Abstract><Full article>