2019

  1. Ostroff LE, Santini E, Sears R, Deane Z, Kanadia RN, LeDoux JE, Lhakhang T, Tsirigos A, Heguy A, Klann E. Axon TRAP reveals learning-associated alterations in cortical axonal mRNAs in the lateral amgydala. Elife. 2019 Dec 11;8. pii: e51607. doi: 10.7554/eLife.51607. <Full>

  2. Gu, Y., Piper, W.T., Branigan, L.A. et al. A brainstem-central amygdala circuit underlies defensive responses to learned threats. Mol Psychiatry (2019) doi:10.1038/s41380-019-0599-6

  3. Brown R, Lau H, LeDoux JE. Understanding the Higher-Order Approach to Consciousness. Trends Cogn Sci. 2019 Sep;23(9):754-768

  4. Campese VD, Kim IT, Hou M, Gupta S, Draus C, Kurpas B, Burke K, LeDoux JE. Chemogenetic inhibition reveals that processing relative but not absolute threat requires basal amygdala. J Neurosci. 2019 Sep 6. pii: 2530-18. doi: 10.1523/JNEUROSCI.2530-18.2019.

  5. Richard Brown, Hakwan Lau, Joseph E. LeDoux. The Misunderstood Higher-Order Approach to Consciousness. psyarxiv.com, January 07, 2019.

  6. Matthias Michel, Diane Beck, […]Masatoshi Yoshida . Opportunities and challenges for a maturing science of consciousness Nature Human Behaviourvolume 3, pages104–107 (2019).

2018

  1. Edited by Dean Mobbs, Joseph LeDoux Survival circuits. Current Opinion in Behavioral Sciences. Volume 24, Pages 1-180 (December 2018).

  2. Joseph LeDoux & Nathaniel D. Daw Surviving threats: neural circuit and computational implications of a new taxonomy of defensive behaviour. Nature reviews neuroscience. 2018 Jan 17.

  3. Joseph E LeDoux, Stefan G Hofmann The subjective experience of emotion: a fearful view. Current Opinion in Behavioral Sciences Volume 19, February 2018, Pages 67-72. Nature. 2018 Jul 26. doi: 10.1038/s41586-018-0405-7.

  4. Huynh TN, Santini E, Mojica E, Fink AE, Hall BS, Fetcho RN, Grosenick L, Deisseroth K, LeDoux JE, Liston C, Klann E. Extinction of auditory threat memory triggers activation of p70 S6 kinase 1 in the basolateral nucleus of the amygdala. Mol Psychiatry. 2018 Jun;23(6):1393.

  5. Krypotos AM, Moscarello JM, Sears RM, LeDoux JE, Galatzer-Levy I. A principled method to identify individual differences and behavioral shifts in signaled active avoidance. Learn Mem. 2018 Oct 15;25(11):564-568. doi: 10.1101/lm.047399.118. Print 2018 Nov.

  6. Schiller D, Monfils MH, Raio CM, Johnson DC, LeDoux JE, Phelps EA. Addendum: Preventing the return of fear in humans using reconsolidation update mechanisms. Nature. 2018 Jul 26. doi: 10.1038/s41586-018-0405-7.

  7. Ann E. J N Fink* and Joseph E. LeDoux Beta-adrenergic enhancement of neuronal excitability in the lateral amygdala is developmentally gated.europhysiol. 2018 Jan 17.

2017

  1. Boeke EA, Moscarello JM, LeDoux JE, Phelps EA, Hartley CA. Active Avoidance: Active Avoidance: Neural Mechanisms and Attenuation of Pavlovian Conditioned Responding. J Neurosci. 2017 May 3;37(18):4808-4818.. <Abstract><Full>

  2. Vincent D. Campese, Jose M Soroeta, Elena M Vazey, Gary Aston-Jones, Joseph E LeDoux and Robert M Sears. Noradrenergic Regulation of central Amygdala in Aversive Pavlovian-to-Instrumental Transfer . eNeuro 13 October 2017 <Full>

  3. Vincent D. Campese, Ian T. Kim, Gerardo Rojas and Joseph E. LeDoux. Pavlovian Extinction and Recovery Effects in Aversive Pavlovian to Instrumental Transfer . Front. Behav. Neurosci., 25 September 2017 <Full>

  4. Dallérac G1, Graupner M2, Knippenberg J1, Martinez RC3, Tavares TF1, Tallot L1, El Massioui N1, Verschueren A1, Höhn S1, Bertolus JB1,4, Reyes A2, LeDoux JE2,5, Schafe GE6, Diaz-Mataix L2& Doyère V1. Updating temporal expectancy of an aversive event engages striatal plasticity under amygdala control . Nat Commun. 2017 Jan 9;8:13920. doi: 10.1038/ncomms13920. <Abstract><Full>

  5. Díaz-Mataix L Piper WT, Schiff HC, Roberts CH, Campese VD, Sears RM, LeDoux JE. Characterization of the amplificatory effect of norepinephrine in the acquisition of Pavlovian threat associations. Learn Mem. 2017 Aug 16;24(9):432-439. doi: 10.1101/lm.044412.116. Print 2017 Sep <Abstract><Full>

  6. Huynh TN, Santini E, Mojica E, Fink AE, Hall BS, Fetcho RN, Grosenick L, Deisseroth K, LeDoux JE, Liston C, Klann E. Activation of a novel p70 S6 kinase 1-dependent intracellular cascade in the basolateral nucleus of the amygdala is required for the acquisition of extinction memory. Mol Psychiatry. 2017 May 2. doi: 10.1038/mp.2017.99. [Epub ahead of print] <Abstract><Full>

  7. Joseph LeDoux Semantics, Surplus Meaning, and the Science of Fear. Trends Cogn Sci. 2017 May;21(5):303-306. doi: 10.1016/j.tics.2017. <Full>

  8. Joseph LeDoux and Richard Brownc A higher-order theory of emotional consciousness. March 16,2017, Trends in Cognitive Sciences. <Full>

  9. Ostroff LE, Botsford B, Gindina S, Cowansage KK, LeDoux JE, Klann E, Hoeffer C. Accumulation of polyribosomes in dendritic spine heads, but not bases and necks, during memory consolidation depends on cap-dependent translation initiation. J Neurosci. 2017 Jan 13. pii: 3301-16. doi:10.1523/JNEUROSCI.3301-16.2017. <Abstract><Full>

  10. Pine DS, LeDoux JE. Elevating the Role of Subjective Experience in the Clinic: Response to Fanselow and Pennington. Am J Psychiatry. 2017 Nov 1;174(11):1121-1122. doi: 10.1176/ <Full>

  11. Tallot L, Diaz-Mataix L, Perry RE, Wood K, LeDoux JE, Mouly AM, Sullivan RM, Doyère V. Updating of aversive memories after temporal error detection is differentially modulated by mTOR across development. Learn Mem. 2017 Feb 15;24(3):115-122. doi: 10.1101/lm.043083.116. Print 2017 Mar. <Abstract>

  12. Wigestrand MB, Schiff HC, Fyhn M, LeDoux JE, Sears RM. Primary auditory cortex regulates threat memory specificity. Learn Mem. 2016 Dec 15;24(1):55-58. doi: 10.1101/lm.044362.116. Print 2017 Jan. <Abstract><Full>


2016

  1. Vincent D. Campese , Robert M. Sears, Justin M. Moscarello, Lorenzo Diaz-Mataix, Christopher K. Cain, Joseph E. LeDoux The Neural Foundations of Reaction and Action in Aversive Motivation . Curr Top Behav Neurosci. 2016;27:171-95. doi: 10.1007/7854_2015_401. Review. <Full>

  2. Kroes MC, Schiller D, LeDoux JE, Phelps EA. Translational Approaches Targeting Reconsolidation.Curr Top Behav Neurosci. 2016 May 31.< Abstract > <Full>

  3. Madarasz TJ, Diaz-Mataix L, Akhand O, Ycu EA, LeDoux JE, Johansen JP. Evaluation of ambiguous associations in the amygdala by learning the structure of the environment. Nat Neurosci. 2016 Jul;19(7):965-72. doi: 10.1038/nn.4308. Epub 2016 May 23.<Abstract><Full>

  4. LeDoux JE J Moscarello, R Sears and V Campese. The birth, death and resurrection of avoidance: a reconceptualization of a troubled paradigm Molecular Psychiatry advance online publication 18 October 2016; doi: 10.1038/mp.2016.166 <Full>

  5. Joseph E. LeDoux, Daniel S. Pine. Using Neuroscience to Help Understand Fear and Anxiety: A Two-System Framework Am J Psychiatry, September 09, 2016<Full>

  6. Schiff HC, Johansen JP, Hou M, Bush DE, Smith EK, Klein JE, LeDoux JE, Sears RM. ß-Adrenergic Receptors Regulate the Acquisition and Consolidation Phases of Aversive Memory Formation through Distinct, Temporally-Regulated Signaling Pathways. Neuropsychopharmacology. 2016 Oct 20. doi: 10.1038/npp.2016.238.<Full>

  7. Wigestrand MB, Schiff HC, Fyhn M, LeDoux JE, Sears RM.. Primary auditory cortex regulates threat memory specificity. Learn Mem. 2016 Dec 15;24(1):55-58. doi: 10.1101/lm.044362.116.<Full>


2015

  1. Campese VD, Gonzaga R, Moscarello JM, LeDoux JE. Modulation of instrumental responding by a conditioned threat stimulus requires lateral and central amygdala . Front. Behav. Neurosci., 30 October 2015 <Abstract><Full>

  2. Dunsmoor JE, Campese VD, Ceceli AO, LeDoux JE, Phelps EA. Novelty-Facilitated Extinction: Providing a Novel Outcome in Place of an Expected Threat Diminishes Recovery of Defensive Response. Biol Psychiatry. 2015 Aug 1;78(3):203-9<Abstract> <Full>

  3. Joseph E. LeDoux. Feelings: What Are They & How Does the Brain Make Them?DAED_a_00319 © 2015 by the American Academy of Arts & Sciences doi: 10.1162<Full>

  4. Ramirez F., Moscarello JM, LeDoux JE, Sears RM Active avoidance requires a serial Basal amygdala to nucleus accumbens shell circuit. J Neurosci. 2015 Feb 25;35(8):3470-7. doi: 10.1523/JNEUROSCI.1331-14.2015.<Abstract> <Full>


2014

  1. Apergis-Schoute AM, Schiller D, Ledoux JE, Phelps EA.Extinction resistant changes in the human auditory association cortex following threat learning. <Abstract><Full>

  2. Johansen JP, Diaz-Mataix L, Hamanaka H, Ozawa T, Ycu E, Koivumaa J, Kumar A, Hou M, Deisseroth K, Boyden ES, LeDoux JE. Hebbian and neuromodulatory mechanisms interact to trigger associative memory formation. Proc Natl Acad Sci U S A. 2014 Dec 8. pii: 201421304.<Abstract><Full>

  3. LeDoux JE. Coming to terms with fear.PNAS 2014:1400335111v1-201400335. <Abstract><Full>

  4. LeDoux J. Low roads and higher order thoughts in emotion. Cortex. 2014 Oct;59:214-5. doi: 10.1016/j.cortex.2014.06.008. Epub 2014 Jun 17. <Full>

  5. Galatzer-Levy IR, Moscarello J, Blessing EM, Klein J, Cain CK, LeDoux JE. Heterogeneity in signaled active avoidance learning: substantive and methodological relevance of diversity in instrumental defensive responses to threat cues. Front Syst Neurosci. 2014 Sep 24;8:179. doi: 10.3389/fnsys.2014.00179. eCollection 2014.Abstract><Full>

  6. Ostroff LE, Manzur MK, Cain CK, Ledoux JE. Synapses lacking astrocyte appear in the amygdala during consolidation of Pavlovian threat conditioning. J Comp Neurol. 2014 Jun 15;522(9):2152-63. doi: 10.1002/cne.23523.<Abstract><Full>

  7. McCue MG, LeDoux JE, Cain CK. Medial amygdala lesions selectively block aversive pavlovian-instrumental transfer in rats.Front Behav Neurosci. 2014 Sep 18;8:329. doi: 10.3389/fnbeh.2014.00329. eCollection 2014.<Abstract><Full>

  8. Moscarello JM, LeDoux J. Diverse Effects of Conditioned Threat Stimuli on Behavior. Cold Spring Harb Symp Quant Biol. 2014;79:11-9. <Abstract><Full>

  9. Sears RM, Schiff HC, LeDoux JE. Molecular mechanisms of threat learning in the lateral nucleus of the amygdala. Prog Mol Biol Transl Sci. 2014;122:263-304. doi: 10.1016/B978-0-12-420170-5.00010-6.<Abstract><Full>

  10. Vincent D Campese, Jeanny Kim, Gabriel Lazaro-Munoz, Lashawn Pena, Joseph E LeDoux and Christopher K Cain. Lesions of lateral or central amygdala abolish aversive Pavlovian-to-instrumental transfer in rats. Front. Behav. Neurosci., 07 May 2014. < Abstract><Full>

2013

Alberini CM, LeDoux JE. Memory reconsolidation. Curr Biol. 2013 Sep 9;23(17):R746-50. doi: 10.1016/j.cub.2013.06.046.<Abstract><Full>

Vincent Campese, Margaret McCue, Gabriel Lazaro-Munoz, Joseph LeDoux and Christopher Cain.Development of an aversive Pavlovian-to-instrumental transfer task in rat. Front. Behav. Neurosci. doi: 10.3389/fnbeh.2013.00176 .<Abstract><Full>

Cowansage KK, Bush DE, Josselyn SA, Klann E, Ledoux JE. Basal variability in CREB phosphorylation predicts trait-like differences in amygdala-dependent memory.Proc Natl Acad Sci U S A. 2013 Oct 8;110(41):16645-50. doi: 10.1073/pnas.1304665110. Epub 2013 Sep 23.<Abstract><Full>

Debiec J, Diaz-Mataix L, Bush DE, Doyère V, LeDoux JE. The selectivity of aversive memory reconsolidation and extinction processes depends on the initial encoding of the Pavlovian association. Learn Mem. 2013 Nov 19;20(12):695-9. doi: 10.1101/lm.031609.113. <Abstract><Full>

Díaz-Mataix L, Ruiz Martinez RC, Schafe GE, Ledoux JE, Doyère V. Detection of a Temporal Error Triggers Reconsolidation of Amygdala-Dependent Memories. Curr Biol. 2013 Feb 26. doi:pii: S0960-9822(13)00088-2. 10.1016/j.cub.2013.01.053. <Abstract><Full>

Galatzer-Levy IR, Bonanno GA, Bush DE, LeDoux JE.Heterogeneity in threat extinction learning: substantive and methodological considerations for identifying individual difference in response to stress.Front Behav Neurosci. 2013 May 29;7:55. doi: 10.3389/fnbeh.2013.00055. Print 2013.<Abstract><Full>

LeDoux JE. The slippery slope of fear. Trends Cogn Sci. 2013 Mar 8. doi:pii: S1364-6613(13)00046-6. 10.1016/j.tics.2013.02.004 <Abstract><Full>

Martinez RC, Gupta N, Lázaro-Muñoz G, Sears RM, Kim S, Moscarello JM, Ledoux JE, Cain CK. Active vs. reactive threat responding is associated with differential c-Fos expression in specific regions of amygdala and prefrontal cortex. Learn Mem. 2013 Jul 18;20(8):446-52. doi: 10.1101/lm.031047.113.

Moscarello JM, LeDoux JE. Active avoidance learning requires prefrontal suppression of amygdala-mediated defensive reactions.J Neurosci. 2013 Feb 27;33(9):3815-23. doi: 10.1523/JNEUROSCI.2596-12.2013. <Abstract><Full>

Daniela Schiller,Jonathan W. Kanen,Joseph E. LeDoux,Marie-H. Monfils, and Elizabeth A. Phelps. Extinction during reconsolidation of threat memory diminishes prefrontal cortex involvement PNASNovember 25, 2013 . <Abstract><Full>

Sears RM, Fink AE, Wigestrand MB, Farb CR, de Lecea L, Ledoux JE. Orexin/hypocretin system modulates amygdala-dependent threat learning through the locus coeruleus Proc Natl Acad Sci U S A. 2013 Nov 25 . <Abstract><Full>

2012

Erlich JC, Bush DE, Ledoux JE. The role of the lateral amygdala in the retrieval and maintenance of fear-memories formed by repeated probabilistic reinforcement. Front Behav Neurosci. 2012;6:16. Epub 2012 Apr 10. <Abstract><Full>

Isogawa K, Bush DE, Ledoux JE Contrasting Effects of Pretraining, Posttraining, and Pretesting Infusions of Corticotropin-Releasing Factor into the Lateral Amygdala: Attenuation of Fear Memory Formation but Facilitation of its Expression. Biol Psychiatry. 2012 Oct 1. pii: S0006-3223(12)00758-5. doi: 10.1016/j.biopsych.2012.08.021.<Abstract><Full>

Martinez RC, Gupta N, Lázaro-Muñoz G, Sears RM, Kim S, Moscarello JM, Ledoux JE, Cain CK. Active vs. reactive threat responding is associated with differential c-Fos expression in specific regions of amygdala and prefrontal cortex. Learn Mem. 2013 Jul 18;20(8):446-52. doi: 10.1101/lm.031047.113.

Galatzer-Levy IR, Bonanno GA, Bush DE, LeDoux JE.Heterogeneity in threat extinction learning: substantive and methodological considerations for identifying individual difference in response to stress.Front Behav Neurosci. 2013 May 29;7:55. doi: 10.3389/fnbeh.2013.00055. Print 2013.<Abstract><Full>

LeDoux JE. Rethinking the Emotional Brain. Neuron, Volume 73, Issue 4, Pages 653-676, Publication Date 23 February 2012 Copyright © 2012 Elsevier Inc. All rights reserved. DOI: 10.1016/j.neuron.2012.02.004 <Read the Article.pdf>

Burghardt NS, Sigurdsson T, Gorman JM, McEwen BS, Ledoux JE. Chronic Antidepressant Treatment Impairs the Acquisition of Fear Extinction. Biol Psychiatry. 2012 Dec 19. doi:pii: S0006-3223(12)00925-0. 10.1016/j.biopsych.2012.10.012.<Abstract><Full>

Ostroff LE, Cain CK, Jindal N, Dar N, Ledoux JE.Stability of presynaptic vesicle pools and changes in synapse morphology in the amygdala following fear learning in adult rats.J Comp Neurol. 2012 Feb 1;520(2):295-314. doi: 10.1002/cne.22691. <Abstract><Full>